COVID-19 clinical presentation <div class="redbox"> <p style="text-size:12px;">COVID-19 can present with a myriad of symptoms so should probably be on most differential diagnosis lists during the pandemic</p> <li><a href="" target="_blank">COVID assessment, DDx and complications</a></li> <li><a href="" target="_blank">Clinical presentation summary infographic</a></li> <div>

Regional lymphadenopathy DDx Image

Red flags
  • Persistent lymphadenopathy > 3weeks
  • Systemic symptoms (fever, night sweats, weight loss)
  • Malignant feeling lymph node
  • Lymph node increasing in size or > 2cm
  • Generalised widespread lymphadenopathy
Investigations to consider
  • FBC & Blood film, CRP/ ESR
  • Glandular fever screen
  • U&Es, LFTs, LDH
  • Viral serology (including HIV)
  • Antibody screen
  • Blood cultures
  • Mantoux test
  • CXR
  • USS
  • CT scan (Chest, abdomen & pelvis)
  • FNAC of lymph node
  • Biopsy
* DDx list disclaimer: please read
  • These lists could never be comprehensive and remain practical to use during the consultation. We have included conditions that we think will cover the vast majority of primary care presentations for any given symptom. This does not mean other conditions, red flags and investigations should not be considered.
  • Each list is provided as a brief reminder only and is presented in no particular order. The authors have used editorial licence to allow quicker access during the consultation and to prevent duplication.
  • We feel that the "Must not Miss" conditions should always appear at the top of your differential diagnosis list. The consequences of missing a diagnosis from within this category carry significant morbidity and mortality risks to your patient.
  • Many diagnoses are not obvious or apparent at the initial presentation. It may be appropriate to share your diagnostic uncertainty with patient, and also provide specific guidance (safety netting) on when and where patients should seek further advice and follow up.